Modeling Course-Based Undergraduate Research Experiences: An Agenda for Future Research and Evaluation

Course-based undergraduate research experiences (CUREs) are being championed as scalable ways of involving undergraduates in science research. Studies of CUREs have shown that participating students achieve many of the same outcomes as students who complete research internships. However, CUREs vary widely in their design and implementation, and aspects of CUREs that are necessary and sufficient to achieve desired student outcomes have not been elucidated. To guide future research aimed at understanding the causal mechanisms underlying CURE efficacy, we used a systems approach to generate pathway models representing hypotheses of how CURE outcomes are achieved. We started by reviewing studies of CUREs and research internships to generate a comprehensive set of outcomes of research experiences, determining the level of evidence supporting each outcome. We then used this body of research and drew from learning theory to hypothesize connections between what students do during CUREs and the outcomes that have the best empirical support. We offer these models as hypotheses for the CURE community to test, revise, elaborate, or refute. We also cite instruments that are ready to use in CURE assessment and note gaps for which instruments need to be developed.Howard Hughes Medical InstituteScience and Mathematics Educatio

THE EFFECTS ON PEASANT HOUSEHOLDS OF ACCESS TO FORMAL DEPOSITS AND LOANS

A dynamic, stochastic, rational expectations model of a peasant household with access to deposits and loans (up to a credit limit) is solved and simulated. If formal contracts offer more favorable rates than informal contracts, then access to formal contracts increases average consumption and decreases its standard deviation.Agricultural Finance, Consumer/Household Economics,

SDSS-IV MaNGA: The intrinsic shape of slow rotator early-type galaxies

By inverting the distributions of galaxies' apparent ellipticities and misalignment angles (measured around the projected half-light radius $R_{\rm e}$) between their photometric and kinematic axes, we study the intrinsic shape distribution of 189 slow rotator early-type galaxies with stellar masses $2\times 10^{11} M_{\odot}<M_\ast<2\times 10^{12} M_{\odot}$, extracted from a sample of about 2200 galaxies with integral-field stellar kinematics from the DR14 of the SDSS-IV MaNGA IFU survey. Thanks to the large sample of slow rotators, Graham+18 showed that there is clear structure in the misalignment angle distribution, with two peaks at both $0^{\circ}$ and $90^{\circ}$ misalignment (characteristic of oblate and prolate rotation respectively). Here we invert the observed distribution from Graham+18. The large sample allows us to go beyond the known fact that slow rotators are weakly triaxial and to place useful constraints on their intrinsic triaxiality distribution (around $1R_{\rm e}$) for the first time. The shape inversion is generally non-unique. However, we find that, for a wide set of model assumptions, the observed distribution clearly requires a dominant triaxial-oblate population. For some of our models, the data suggest a hint for a minor triaxial-prolate population, but a dominant prolate population is ruled out.Comment: Accepted for publication in ApJL, 10 pages, 4 figures, 1 tabl

New Perspective on Passively Quenched Single Photon Avalanche Diodes: Effect of Feedback on Impact Ionization

Single-photon avalanche diodes (SPADs) are primary devices in photon counting systems used in quantum cryptography, time resolved spectroscopy and photon counting optical communication. SPADs convert each photo-generated electron hole pair to a measurable current via an avalanche of impact ionizations. In this paper, a stochastically self-regulating avalanche model for passively quenched SPADs is presented. The model predicts, in qualitative agreement with experiments, three important phenomena that traditional models are unable to predict. These are: (1) an oscillatory behavior of the persistent avalanche current; (2) an exponential (memoryless) decay of the probability density function of the stochastic quenching time of the persistent avalanche current; and (3) a fast collapse of the avalanche current, under strong feedback conditions, preventing the development of a persistent avalanche current. The model specifically captures the effect of the load’s feedback on the stochastic avalanche multiplication, an effect believed to be key in breaking today’s counting rate barrier in the 1.55–μm detection window

The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease

AbstractEthics on animal use in science in Western society is based on utilitarianism, weighing the harms and benefits to the animals involved against those of the intended human beneficiaries. The 3Rs concept (Replacement, Reduction, Refinement) is both a robust framework for minimizing animal use and suffering (addressing the harms to animals) and a means of supporting high quality science and translation (addressing the benefits). The ambiguity of basic research performed early in the research continuum can sometimes make harm-benefit analysis more difficult since anticipated benefit is often an incremental contribution to a field of knowledge. On the other hand, benefit is much more evident in translational research aimed at developing treatments for direct application in humans or animals suffering from disease. Though benefit may be easier to define, it should certainly not be considered automatic. Issues related to model validity seriously compromise experiments and have been implicated as a major impediment in translation, especially in complex disease models where harms to animals can be intensified. Increased investment and activity in the 3Rs is delivering new research models, tools and approaches with reduced reliance on animal use, improved animal welfare, and improved scientific and predictive value

Prosomal-width-to-weight relationships in American horseshoe crabs (Limulus polyphemus): examining conversion factors used to estimate landings

Horseshoe crabs (Limulus polyphemus) are valued by many stakeholders, including the commercial fishing industry, biomedical companies, and environmental interest groups. We designed a study to test the accuracy of the conversion factors that were used by NOAA Fisheries and state agencies to estimate horseshoe crab landings before mandatory reporting that began in 1998. Our results indicate that the NOAA Fisheries conversion factor consistently overestimates the weight of male horseshoe crabs, particularly those from New England populations. Because of the inaccuracy of this and other conversion factors, states are now mandated to report the number (not biomass) and sex of landed horseshoe crabs. However, accurate estimates of biomass are still necessary for use in prediction models that are being developed to better manage the horseshoe crab fishery. We recommend that managers use the conversion factors presented in this study to convert current landing data from numbers to biomass of harvested horseshoe crabs for future assessments

Food Habits of Ermine, Mustela erminea, in a Forested Landscape

Most research pertaining to the diet of North American weasels has been conducted in agricultural areas and may not be representative of diets in forested regions. Ermine carcasses (N = 155) collected from trappers during a two-week harvest (16-30 November 1996) in forested New Brunswick were analyzed for food habits. The contents of 81 stomachs and 98 gastrointestinal tracts (N = 179) were considered as separate eating events and used in the calculation of the percent frequency of occurrence. Results suggest that soricids (28.0%), arvicolines (24.6%), and cricetines (17.3%) comprised two-thirds of their autumn diet. At a species or genus level, the Deer Mouse (Peromyscus maniculatus) (17.3%) and shrews (Sorex spp.) (28.0%) were shown to have the highest percent occurrence. Squirrels, including the Red Squirrel (Tamiasciurus hudsonicus) and the Eastern Chipmunk (Tamius striatus), comprised 11.2% of the Ermine&rsquo;s diet; a value higher than has previously been reported

Elevated ACKR2 expression is a common feature of inflammatory arthropathies

Objectives. Chemokines are essential contributors to leucocyte accumulation at sites of inflammatory pathology. Interfering with chemokine or chemokine receptor function therefore represents a plausible therapeutic option. However, our currently limited understanding of chemokine orchestration of inflammatory responses means that such therapies have not yet been fully developed. We have a particular interest in the family of atypical chemokine receptors that fine-tune, or resolve, chemokine-driven responses. In particular we are interested in atypical chemokine receptor 2 (ACKR2), which is a scavenging receptor for inflammatory CC-chemokines and that therefore helps to resolve in vivo inflammatory responses. The objective of the current study was to examine ACKR2 expression in common arthropathies. Methods. ACKR2 expression was measured by a combination of qPCR and immuno-histochemistry. In addition, circulating cytokine and chemokine levels in patient plasma were assessed using multiplexing approaches. Results. Expression of ACKR2 was elevated on peripheral blood cells as well as on leucocytes and stromal cells in synovial tissue. Expression on peripheral blood leucocytes correlated with, and could be regulated by, circulating cytokines with particularly strong associations being seen with IL-6 and hepatocyte growth factor. In addition, expression within the synovium was coincident with aggregates of lymphocytes, potentially atopic follicles and sites of high inflammatory chemokine expression. Similarly increased levels of ACKR2 have been reported in psoriasis and SSc. Conclusion. Our data clearly show increased ACKR2 in a variety of arthropathies and taking into account our, and others’, previous data we now propose that elevated ACKR2 expression is a common feature of inflammatory pathologies